1 中国科学院空天信息创新研究院 国家环境保护卫星遥感重点实验室，北京 100101
2 中国科学院大学，北京 ，100049
3 中国空间技术研究院 遥感卫星总体部，北京 100094
4 北京环境特性研究所 光学辐射重点实验室，北京 100854
5 南京工业大学 测绘科学与技术学院，江苏 南京 211816
6 昆明学院 信息技术学院，云南 昆明 650214
作为可见光-近红外和热红外的连接谱段，中红外（MIR）兼具短波辐射的反射特性和长波辐射的发射特性，对于温度探测、目标识别等应用场景有十分重要的意义。目前，MIR谱段辐射传输（RT）计算仍然面临背景参数输入多且不易获取的问题。基于此，提出了一种应用于卫星MIR遥感的RT简化计算方案。使用MODTRAN模型（MM），对MIR白天RT过程中所涉及的背景地表和大气参数定量模拟分析，得到影响RT的关键参数，据此形成一套基于MM的参数简化方案（SS）。在MODIS 6个MIR通道的中心波长处，对SS和MM计算的总辐亮度做对比验证，RMSE均小于0.004399，具有较高精度。SS仅依赖于表面温度、表面发射率、大气廓线类型、水汽和云光学厚度，不需要输入气溶胶、CO2和O3数据。相比MM，SS将输入参数从8类降低到5类，计算的时间效率提升了9.02%。在有限的计算资源下，本文所提的SS能够为MIR图像快速处理、大场景遥感仿真等应用领域提供支撑。
中红外（MIR）谱段 辐射传输（RT）计算 背景参数 简化方案（SS） mid-infrared（MIR） spectrum radiative transfer（RT） calculation background parameters simplified scheme（SS）
Author Affiliations
Abstract
1 Beijing Key Laboratory of Environmental Science and Engineering, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, People’s Republic of China
2 Advanced Technology Research Institute, Beijing Institute of Technology, Jinan 250300, People’s Republic of China
3 Collaborative Innovation Center of Electric Vehicles in Beijing, Beijing, 100081, People’s Republic of China
4 Institute of Electronic Engineering, China Academy of Engineering Physics, Mianyang 621900, People’s Republic of China
Aqueous Zn2+-ion batteries (AZIBs), recognized for their high security, reliability, and cost efficiency, have garnered considerable attention. However, the prevalent issues of dendrite growth and parasitic reactions at the Zn electrode interface significantly impede their practical application. In this study, we introduced a ubiquitous biomolecule of phenylalanine (Phe) into the electrolyte as a multifunctional additive to improve the reversibility of the Zn anode. Leveraging its exceptional nucleophilic characteristics, Phe molecules tend to coordinate with Zn2+ ions for optimizing the solvation environment. Simultaneously, the distinctive lipophilicity of aromatic amino acids empowers Phe with a higher adsorption energy, enabling the construction of a multifunctional protective interphase. The hydrophobic benzene ring ligands act as cleaners for repelling H2O molecules, while the hydrophilic hydroxyl and carboxyl groups attract Zn2+ ions for homogenizing Zn2+ flux. Moreover, the preferential reduction of Phe molecules prior to H2O facilitates the in situ formation of an organic–inorganic hybrid solid electrolyte interphase, enhancing the interfacial stability of the Zn anode. Consequently, Zn||Zn cells display improved reversibility, achieving an extended cycle life of 5250 h. Additionally, Zn||LMO full cells exhibit enhanced cyclability of retaining 77.3% capacity after 300 cycles, demonstrating substantial potential in advancing the commercialization of AZIBs.
Nano-Micro Letters
2024, 16(1): 164
1 南京医科大学，附属江宁医院呼吸与危重症医学科，南京 211100
2 生物医学工程与信息学院，南京 211100
3 附属江宁医院中心实验室, 南京 211100
肿瘤微环境呈现出一个错综复杂的生态系统, 包括肿瘤细胞、非癌细胞、细胞外基质以及微生物群落等多种要素。微生物在肿瘤内广泛分布, 其在空间分布上呈现出显著的特异性。这些微生物的组成成分与功能状态在肿瘤的发生和进展中发挥着至关重要的作用。本文深入阐明了肿瘤微环境内微生物菌群的特征, 并探索其对肿瘤发生发展的影响机制, 以期为肿瘤的诊断和治疗提供全新的策略和视角。
肿瘤 肿瘤微环境 微生物 微生物群落 肿瘤诊疗 tumor tumor microenvironment microbe microbial community oncology treatment
1 江苏医药职业学院江宁临床医学院呼吸与危重症医学科，南京 211100
2 南京医科大学附属江宁医院药学部，南京 211100
3 南京市高淳人民医院呼吸与危重症医学科，南京 211300
硫利达嗪作为吩噻嗪类抗精神病类药物，具有诱导肿瘤发生免疫原性死亡（ ICD）、激活特异性免疫反应的潜力。本研究利用 A549和 H1299细胞探讨了硫利达嗪诱导肺腺癌细胞免疫原性死亡及其分子机制。将不同浓度的硫利达嗪与 A549和 H1299细胞共孵育 24 h后，利用四甲基偶氮唑蓝（ MTT）法检测细胞的存活及生长情况，利用流式细胞术分析细胞凋亡率，利用 ATP检测试剂盒检测细胞上清中的 ATP含量，利用免疫荧光法检测细胞表面钙网蛋白（ CRT）的表达，利用蛋白质印迹（ Western blot）法检测凋亡相关蛋白裂解的含半胱氨酸的天冬氨酸蛋白水解酶 3（Cleaved caspase 3）、B淋巴细胞瘤 -2（Bcl-2）、Bcl-2相关 X蛋白（ Bax）、细胞色素 C（Cyt C）的表达水平。结果表明，硫利达嗪能够显著抑制 A549和 H1299细胞的增殖，促进细胞凋亡，细胞增殖抑制及凋亡呈浓度依赖性。 ATP分泌量增加及细胞表面 CRT的表达水平上调，表明上述细胞发生了免疫原性死亡。而 Bcl-2表达水平下降， Bax和 Cyt C以及 Cleaved caspase 3表达水平上调，进一步证明了硫利达嗪可诱导肿瘤细胞凋亡。上述结果表明，硫利达嗪可通过线粒体应激信号通路诱导肺腺癌细胞发生免疫原性死亡，从而抑制肿瘤细胞的增殖。
肺腺癌 硫利达嗪 免疫原性死亡 线粒体应激信号通路 凋亡细胞 lung adenocarcinoma Thioridazine immunogenic cell death mitochondrial stress signaling pathway apoptotic cell
云南北方奥雷德光电科技股份有限公司, 云南昆明 650223
叠层有机发光二极管(Organic Light-Emitting Diode, OLED)白光器件具备低功耗、高亮度、高色域等性能优势。然而, 由于效率、寿命及驱动电压等性能仍有较大改进空间, 叠层结构的材料及电学结构仍需进一步优化。本文重点介绍叠层 OLED白光器件的最新研究进展, 总结了三类电荷产生层(Charge Generation Layer, CGL)在工程化应用中存在的问题以及其非破坏性检测方法; 综述高效叠层 OLED白光器件的“全磷光体系”、“并行通道激子收集”及“混合磷光热活性型延迟荧光(Thermally Activated Delayed Fluorescence, TADF)体系”最新研究成果, 对器件寿命问题进行总结, 探讨分析“分级掺杂”、“四色混合 TADF体系”等从结构方面提出优化方案, 并针对不同发光材料体系中的 CGL材料及结构综述叠层 OLED白光器件实现较低工作电压的技术方法, 最后对叠层 OLED白光器件的材料和结构提出改进建议。
叠层白光有机发光二极管 电荷产生层 有机发光单元 功能层结构 有机发光材料 tandem white OLEDs, CGL, Emitting Layer unit, func
1 南宁师范大学化学与材料学院, 广西 南宁 530100
2 广西壮族自治区生殖医院, 广西 南宁 530218
氨基硫脲过渡金属配合物的生物学应用是当前研究的热点, 为更好地了解氨基硫脲芳基钌配合物与人血清白蛋白(HSA)之间相互作用机制, 合成了两种氨基硫脲芳基钌(Ⅱ)配合物, 采用时间分辨荧光光谱法和稳态荧光光谱法研究了两种氨基硫脲芳基钌配合物与人血清白蛋白的荧光猝灭机理。 荧光光谱结果表明, 这两种氨基硫脲芳基钌配合物能使HSA的内源荧光猝灭, 且HSA的荧光猝灭影响与配合物的浓度呈线性关系, 通过对比发现配合物2对HSA的荧光猝灭效率更强。 两个配合物与HSA相互作用的猝灭常数和结合常数均随温度的升高而降低, 因此, 配合物与HSA的相互作用是静态猝灭过程, 且配合物2的荧光猝灭能力更强。 通过热力学参数分析发现这两种配合物与HSA的主要结合作用力均为氢键和范德华力, 且两种配合物与HSA之间的结合过程是自发进行的。 最后采用红外吸收光谱及圆二色光谱验证了这两种氨基硫脲芳基钌配合物均对HSA二级构象产生了不同程度的影响, 红外吸收光谱结果表明两种配合物与HSA的结合引起了HSA二级结构的重排, 圆二色光谱结果表明这两种配合物的加入使HSA的二级结构稳定性降低。 研究表明: 通过探究氨基硫脲芳基钌配合物对人血清白蛋白结构和功能的影响, 可揭示其作为抗肿瘤药物进入体内后与HSA的可能作用机制, 从而为以氨基硫脲为配体的芳基钌配合物类抗肿瘤药物的研发提供理论参考。
氨基硫脲 芳基钌 人血清白蛋白 相互作用 Thiosemicarbazide Ruthenium Human serum albumin Interaction 光谱学与光谱分析
2023, 43(9): 2761
1 中国科学院 光电技术研究所, 四川 成都 610000
2 西南技术物理研究所, 四川 成都 610000
星-地激光通信具有通信距离远、传输信道复杂等特点, 为建立稳定可靠的星-地激光通信链路, 需要建立大口径的地面站。着重研究了地面站中500mm大口径主镜柔性支撑的点位分布及结构尺寸。让主镜组件既满足刚度需求, 也具有柔度缓解其自身动态误差。在Isight平台建立光机热耦合的优化流程。运用Zernike多项式拟合面形得到精准的镜面RMS值; 并以此为优化目标, 获取柔性支撑点位的最优解及柔性杆尺寸参数的最优解。经过优化, 主镜组件可适应温度范围扩大了约30℃; 在俯仰角度变化下, 主镜RMS值下降约2nm。对设备进行了相关试验, 主镜面形均满足指标要求小于0.08λ。
激光通信 主镜面形 动态误差 光机热耦合 柔性支撑优化设计 laser communication main mirror shape dynamic error optical, mechanical and thermal coupling optimal design of the flexible support
强激光与粒子束
2023, 35(9): 091001
Author Affiliations
Abstract
1 Department of Ophthalmology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, P. R. China
2 Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, P. R. China
3 China Academy of Industrial Internet, Beijing 100102, P. R. China
4 Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, P. R. China
Scarring is one of the biggest areas of unmet need in the long-term success of glaucoma filtration surgery. Quantitative evaluation of the scar tissue and the post-operative structure with micron scale resolution facilitates development of anti-fibrosis techniques. However, the distinguishment of conjunctiva, sclera and the scar tissue in the surgical area still relies on pathologists’ experience. Since polarized light imaging is sensitive to anisotropic properties of the media, it is ideal for discrimination of scar in the subconjunctival and episcleral area by characterizing small differences between proportion, organization and the orientation of the fibers. In this paper, we defined the conjunctiva, sclera, and the scar tissue as three target tissues after glaucoma filtration surgery and obtained their polarization characteristics from the tissue sections by a Mueller matrix microscope. Discrimination score based on parameters derived from Mueller matrix and machine learning was calculated and tested as a diagnostic index. As a result, the discrimination score of three target tissues showed significant difference between each other (). The visualization of the discrimination results showed significant contrast between target tissues. This study proved that Mueller matrix imaging is effective in ocular scar discrimination and paves the way for its application on other forms of ocular fibrosis as a substitute or supplementary for clinical practice.
Tissue discrimination glaucoma filtration surgery polarized light Mueller matrix machine learning Journal of Innovative Optical Health Sciences
2023, 16(5): 2241003
Author Affiliations
Abstract
Miniaturized light sources at telecommunication wavelengths are essential components for on-chip optical communication systems. Here, we report the growth and fabrication of highly uniform p-i-n core-shell InGaAs/InP single quantum well (QW) nanowire array light emitting diodes (LEDs) with multi-wavelength and high-speed operations. Two-dimensional cathodoluminescence mapping reveals that axial and radial QWs in the nanowire structure contribute to strong emission at the wavelength of ~1.35 and ~1.55 μm, respectively, ideal for low-loss optical communications. As a result of simultaneous contributions from both axial and radial QWs, broadband electroluminescence emission with a linewidth of 286 nm is achieved with a peak power of ~17 μW. A large spectral blueshift is observed with the increase of applied bias, which is ascribed to the band-filling effect based on device simulation, and enables voltage tunable multi-wavelength operation at the telecommunication wavelength range. Multi-wavelength operation is also achieved by fabricating nanowire array LEDs with different pitch sizes on the same substrate, leading to QW formation with different emission wavelengths. Furthermore, high-speed GHz-level modulation and small pixel size LED are demonstrated, showing the promise for ultrafast operation and ultracompact integration. The voltage and pitch size controlled multi-wavelength high-speed nanowire array LED presents a compact and efficient scheme for developing high-performance nanoscale light sources for future optical communication applications.
InGaAs/InP quantum well nanowires LEDs Opto-Electronic Science
2023, 2(5): 230003
